Inhibiting the inhibitor.

Inhibiting the inhibitor.

Inhibiting the hepcidin inhibitor for treatment of iron overload.

the expression of several homolog isoforms of UGTs in CLL patient samples and in the CLL cell line MEC-1, UGT2B17 mRNA expression was the only isoform expressed to any significant level. UGT2B17 mRNA expression was also shown to directly correlate with its enzymatic activity. Extending the biology further, UGT2B17 RNA silencing in the MEC-1 cell line was pursued followed by analysis of comparat...

New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor

D evelopment of an effective HIV-1 vaccine has been an elusive goal for over 20 years despite being an urgent global priority. The agonizingly slow progress is not from lack of effort, but is a consequence of the insidious biology of the virus. HIV-1 has many features that make vaccine development challenging, if not impossible [1]. Pessimism is based in part on the empirical observation that t...

Quinazoline derivative compound (11d) as a novel angiogenesis inhibitor inhibiting VEGFR2 and blocking VEGFR2-mediated Akt/mTOR /p70s6k signaling pathway

Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. Materials and Methods: We examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (VEGFR2) activation via VEG...

Student Research Projects Inhibiting Factors from the Students Perspective

Background & Objective: Identifying the research barriers and assess the ability of students to use the university services and facilities is crucial to promote research activities. Present study was carried out to determine the inhibiting factors influencing the student's research projects from the view point of Yasuj University of Medical Sciences students in 2008. Materials & Methods: In thi...